Hyperglycemia Exacerbates Intracerebral Hemorrhage via the Downregulation of Aquaporin-4
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چکیده
منابع مشابه
Hyperglycemia exacerbates intracerebral hemorrhage via the downregulation of aquaporin-4: temporal assessment with magnetic resonance imaging.
BACKGROUND AND PURPOSE Intracerebral hemorrhage (ICH) is associated with high mortality and neurological deficits, and concurrent hyperglycemia usually worsens clinical outcomes. Aquaporin-4 (AQP-4) is important in cerebral water movement. Our aim was to investigate the role of AQP-4 in hyperglycemic ICH. METHODS Hyperglycemia was induced by intraperitoneal injection of streptozotocin (STZ; 6...
متن کاملHyperglycemia exacerbates brain edema and perihematomal cell death after intracerebral hemorrhage.
BACKGROUND AND PURPOSE Hyperglycemia has a deleterious effect on brain ischemia. However, the effect of hyperglycemia in intracerebral hemorrhage (ICH) is not well known. We investigated the effect of hyperglycemia on the development of brain edema and perihematomal cell death in ICH. METHODS Hyperglycemia was induced by intraperitoneal injection of streptozotocin (60 mg/kg) in adult Sprague-...
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29 急性脳内出血の予後因子としての高血糖の意義―INTERACT2 試験 Prognostic Significance of Hyperglycemia in Acute Intracerebral HemorrhageThe INTERACT2 Study Anubhav Saxena, MBBS, BSc (Adv)1,2; Craig S. Anderson, MD, PhD1,2 ; Xia Wang, MMed1,2, et al.1 The George Institute for Global Health, Royal Prince Alfred Hospital, Sydney, NSW, Australia; 2Central Clinical School, Univer...
متن کاملPersistent Hyperglycemia Is Associated With Increased Mortality After Intracerebral Hemorrhage
BACKGROUND Hyperglycemia may be associated with worse outcome after intracerebral hemorrhage (ICH). We assessed the association of early glycemic trajectory on ICH mortality and edema growth. METHODS AND RESULTS We included patients from the Helsinki ICH study with glucose measurements at least once between both 0 to 24 and 24 to 72 hours from onset. Hyperglycemia was defined as blood glucose...
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Vascular endothelial growth factor (VEGF) has protective effects on many neurological diseases. However, whether VEGF acts on brain edema following intracerebral hemorrhage (ICH) is largely unknown. Our previous study has shown aquaporin-4 (AQP4) plays an important role in brain edema elimination following ICH. Meanwhile, there is close relationship between VEGF and AQP4. In this study, we aime...
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ژورنال
عنوان ژورنال: Stroke
سال: 2013
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.113.675983